Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment

Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secr...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2021-09, Vol.11 (10), p.1398
Main Authors: Huang, Yanyu, Wang, Hsiao-Chi, Zhao, Junwei, Wu, Ming-Heng, Shih, Tsung-Chieh
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Apoptosis
Binding sites
Cancer
Cytokines
Fatalities
Galectin 1 - antagonists & inhibitors
Galectin 1 - genetics
Galectin 1 - immunology
Galectin-1
Humans
Immunosurveillance
immunotherapy
Immunotherapy - trends
LLS30
Lymphocytes
Lymphoma
microenvironment
Mutation
Neoplasms - genetics
Neoplasms - immunology
Neoplasms - pathology
Neoplasms - therapy
Proteins
Receptor mechanisms
Review
Roles
Tumor cells
Tumor Escape - genetics
Tumor Escape - immunology
Tumor microenvironment
Tumor Microenvironment - genetics
Tumor Microenvironment - immunology
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Summary:Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom11101398