Alteration of perivascular reflectivity on optical coherence tomography of branched retinal vein obstruction

This study aimed to evaluate perivascular reflectivity in patients with branched retinal vascular obstruction (BRVO) using en-face optical coherence tomography (OCT). The study retrospectively analyzed 45 patients with recurrent BRVO, 30 with indolent BRVO, and 45 age- and sex-matched controls. Usin...

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Bibliographic Details
Published in:Scientific reports 2023-09, Vol.13 (1), p.15847-15847, Article 15847
Main Authors: Hwang, Bo-Een, Kim, Joo-Young, Kim, Rae-Young, Kim, Mirinae, Park, Young-Geun, Park, Young-Hoon
Format: Article
Language:English
Subjects:
692/699/3161/3175
692/699/3161/3178
Angiography
Dexamethasone
Face
Humanities and Social Sciences
multidisciplinary
Regression analysis
Retina
Science
Science (multidisciplinary)
Tomography
Vascular endothelial growth factor
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Summary:This study aimed to evaluate perivascular reflectivity in patients with branched retinal vascular obstruction (BRVO) using en-face optical coherence tomography (OCT). The study retrospectively analyzed 45 patients with recurrent BRVO, 30 with indolent BRVO, and 45 age- and sex-matched controls. Using a 3.0 × 3.0-mm deep capillary plexus slab on macular scans, OCT angiography (OCTA) and structural en-face OCT scans were divided into four quadrants. Obstructive quadrants of OCTA scans were binarized using a threshold value of mean + 2 standard deviation. The selected area of high signal strength (HSS) was applied to the structural en-face OCT scans, and the corrected mean perivascular reflectivity was calculated as the mean reflectivity on the HSS area/overall en-face OCT mean reflectivity. The same procedure was performed in the quadrants of the matched controls. Regression analysis was conducted on several factors possibly associated with corrected perivascular reflectivity. The perivascular reflectivity in the obstructive BRVO quadrant was significantly higher than in the indolent BRVO and control quadrants (P = 0.009, P = 0.003). Both univariate and multivariate regression analyses showed a significant correlation between the average number of intravitreal injections (anti-vascular endothelial growth factor or dexamethasone implant) per year and refractive errors and image binarization threshold and perivascular reflectivity (P = 0.011, 0.013,
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-41691-4