No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis

HPV-infection in patients with HNSCC is reportedly correlated with sexual behavior, age, and tobacco/alcohol-consumption. HPV-infections of the oral cavity are regarded as sexually transmitted. Comparable data of patient populations outside the U.S. are sparse or missing. Questionnaires regarding se...

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Bibliographic Details
Published in:Papillomavirus research 2020-12, Vol.10, p.100207, Article 100207
Main Authors: Quabius, Elgar Susanne, Fazel, Asita, Knieling, Christopher, Gebhardt, Stephan, Laudien, Martin, Moore, Crystal, Kühnel, André, Hoppe, Florian, Mlynski, Robert, Heinrichs, Alessa, Fabian, Alexander, Hoffmann, Markus
Format: Article
Language:English
Subjects:
Aged
Carcinogenesis
DNA, Viral - analysis
Educational Status
Female
HPV
Humans
Infection
Male
Middle Aged
Mouth - virology
Oral
Oral sex
Palatine Tonsil - pathology
Palatine Tonsil - virology
Papillomaviridae - genetics
Papillomavirus Infections - complications
Papillomavirus Infections - epidemiology
Papillomavirus Infections - transmission
Papillomavirus Infections - virology
Prospective Studies
Risk Factors
Sexual behavior
Sexual Behavior - statistics & numerical data
Sexual Partners
STD
Surveys and Questionnaires
Tonsillar Neoplasms - epidemiology
Tonsillar Neoplasms - pathology
Tonsillar Neoplasms - virology
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Summary:HPV-infection in patients with HNSCC is reportedly correlated with sexual behavior, age, and tobacco/alcohol-consumption. HPV-infections of the oral cavity are regarded as sexually transmitted. Comparable data of patient populations outside the U.S. are sparse or missing. Questionnaires regarding sexual behavior, education tobacco- and alcohol-consumption, were given to 28 patients with tonsillar hyperplasia (H) and 128 patients with tonsillar carcinomas (CA), all with tissue-typed HPV-DNA-status performing PCR. Answers were correlated among groups and HPV-status. 106 questionnaires were analyzed. Comparisons between H- (n = 25) and CA- (n = 81) patients showed that CA-patients were older (61.1yrs ± 9.3) than H-patients (45.2yrs ± 11.9; p 
ISSN:2405-8521
2405-8521
DOI:10.1016/j.pvr.2020.100207