Smectic-B phase and temperature-driven smectic-B to -A transition in concentrated solutions of “gapped” DNA

The occurrence of a smectic-B (Sm-B) phase is demonstrated in concentrated aqueous solutions of “gapped” DNA constructs consisting of fully paired duplexes bridged by a flexible, unpaired strand of nucleotides. The Sm-B phase, identified by small and wide angle x-ray scattering measurements and opti...

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Bibliographic Details
Published in:Physical review research 2022-07, Vol.4 (3), p.033046, Article 033046
Main Authors: Gyawali, Prabesh, Saha, Rony, Kodikara, Sineth G., Li, Ruipeng, Fukuto, Masafumi, Gleeson, James T., Smith, Gregory P., Clark, Noel A., Jakli, Antal, Balci, Hamza, Sprunt, Samuel
Format: Article
Language:English
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Summary:The occurrence of a smectic-B (Sm-B) phase is demonstrated in concentrated aqueous solutions of “gapped” DNA constructs consisting of fully paired duplexes bridged by a flexible, unpaired strand of nucleotides. The Sm-B phase, identified by small and wide angle x-ray scattering measurements and optical microscopy, develops from a smectic-A (Sm-A) phase with increasing DNA concentration at room temperature. It transitions (reversibly) to the Sm-A when the temperature is raised above ∼50^{∘}C.
ISSN:2643-1564
2643-1564
DOI:10.1103/PhysRevResearch.4.033046