Colonic Basidiobolomycosis-An Unusual Presentation of Eosinophilic Intestinal Inflammation

Basidiobolomycosis is a rare fungal disease caused by . Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disease, primary immunode...

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Bibliographic Details
Published in:Frontiers in pediatrics 2020-04, Vol.8, p.142
Main Authors: Kurteva, Elena, Bamford, Alasdair, Cross, Kate, Watson, Tom, Owens, Catherine, Cheng, Fanlek, Hartley, John, Harris, Kathryn, Johnson, Elizabeth M, Lindley, Keith, Levine, Samantha, Köglmeier, Jutta
Format: Article
Language:English
Subjects:
basidiobolomycosis
children
colon
eosinophilic inflammation
intestine
Pediatrics
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Summary:Basidiobolomycosis is a rare fungal disease caused by . Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disease, primary immunodeficiency, or a malignancy and should be considered in patients who do not respond to standard therapy. We present the case of a 22 months old boy with confirmed colonic Basidiobolomycosis, who presented with severe eosinophilic inflammation of the gastrointestinal tract. Panfungal PCR performed on DNA extracted directly from a tissue sample confirmed the presence of . He made a full recovery with a combination of surgery and prolonged targeted antifungal medication.
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2020.00142