Disseminated fusariosis with cutaneous involvement in hematologic malignancies: report of six cases with high mortality rate

Fusariosis is due to inhalation or direct contact with conidia. Clinical presentation depends on host’s immunity and can be localized, focally invasive or disseminated. Given the severity of this infection and the possibility for the dermatologist to make an early diagnosis, we report six cases of p...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2018-09, Vol.93 (5), p.726-729
Main Authors: Zoéga Hayashida, Marina, Arai Seque, Camila, Simões e Silva Enokihara, Milvia Maria, Maria Porro, Adriana
Format: Article
Language:English
Subjects:
Adult
Antifungal Agents - therapeutic use
Case Report
DERMATOLOGY
Fatal Outcome
Fusariosis
Fusariosis - complications
Fusariosis - pathology
Fusariosis - prevention & control
Fusarium - isolation & purification
Hematologic neoplasms
Humans
Leukemia, Myeloid, Acute - complications
Middle Aged
Multiple Myeloma - complications
Neutropenia
Neutropenia - etiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Skin - microbiology
Skin - pathology
Young Adult
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Summary:Fusariosis is due to inhalation or direct contact with conidia. Clinical presentation depends on host’s immunity and can be localized, focally invasive or disseminated. Given the severity of this infection and the possibility for the dermatologist to make an early diagnosis, we report six cases of patients with hematologic malignancies, who developed febrile neutropenia an skin lesions suggestive of cutaneous fusariosis. All patients had skin cultures showing growth of Fusarium solani complex, and they received amphotericin B and voriconazole. As this infection can quickly lead to death, dermatologists play a crucial role in diagnosing this disease.
ISSN:0365-0596
1806-4841
1806-4841
DOI:10.1590/abd1806-4841.20187476