The Most Common Vitamin D Receptor Polymorphisms ( ApaI, FokI , TaqI , BsmI , and BglI ) in Children with Dental Caries: A Systematic Review and Meta-Analysis

Vitamin D participates in the calcification of enamel and dentin and the appropriate immune responses to oral microbial infections. We aimed to assess the association between the most common vitamin D receptor ( ) polymorphisms ( , , , and ) and the risk of dental caries in children. PubMed/MEDLINE,...

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Published in:Children (Basel) 2021-04, Vol.8 (4), p.302
Main Authors: Sadeghi, Masoud, Golshah, Amin, Godiny, Mostafa, Sharifi, Roohollah, Khavid, Atefeh, Nikkerdar, Nafiseh, Tadakamadla, Santosh Kumar
Format: Article
Language:English
Subjects:
Childrens health
Confidence intervals
Dental caries
Developing countries
Enamel
Genes
Genomes
LDCs
Meta-analysis
Pediatrics
Polymorphism
Proteins
Review
Software
Systematic review
tooth decay
Vitamin D
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Summary:Vitamin D participates in the calcification of enamel and dentin and the appropriate immune responses to oral microbial infections. We aimed to assess the association between the most common vitamin D receptor ( ) polymorphisms ( , , , and ) and the risk of dental caries in children. PubMed/MEDLINE, Cochrane Library, Web of Science, and Scopus databases were comprehensively searched until 19 January 2021. Meta-analysis with odds ratios as the effect estimate along with 95% confidence intervals and subgroup analysis were conducted using Review Manager 5.3 software. Publication bias and sensitivity analyses were conducted by Comprehensive Meta-Analysis, version 2.0 software. Seventy-eight studies were retrieved from the databases, with nine studies included in the final analysis. Based on five genetic models, there was no association between , , , , and polymorphisms and susceptibility to dental caries, except for the polymorphism. Among the polymorphisms considered, an association was found between the polymorphism and the risk of dental caries, with a protective role of the f allele and ff genotype.
ISSN:2227-9067
2227-9067
DOI:10.3390/children8040302