A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control study

Macrophage migration inhibitory factor (MIF) plays an important regulatory role in sepsis. In the promoter region a C/G single nucleotide polymorphism (SNP) at position -173 (rs755622) and a CATT5-8 microsatellite at position -794 are related to modified promoter activity. The purpose of the study w...

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Bibliographic Details
Published in:Journal of translational medicine 2009-11, Vol.7 (1), p.100-100, Article 100
Main Authors: Lehmann, Lutz E, Book, Malte, Hartmann, Wolfgang, Weber, Stefan U, Schewe, Jens-Christian, Klaschik, Sven, Hoeft, Andreas, Stüber, Frank
Format: Article
Language:English
Subjects:
Adolescent
Adult
Case studies
Case-Control Studies
Development and progression
Female
Gene Frequency
Genetic aspects
Genetic Predisposition to Disease
Genotype
Haplotypes
Health aspects
Humans
Lymphokines
Macrophage Migration-Inhibitory Factors - genetics
Male
Middle Aged
Physiological aspects
Polymorphism, Single Nucleotide
Promoter Regions, Genetic - genetics
Risk factors
Sepsis
Sepsis - genetics
Sepsis - mortality
Single nucleotide polymorphisms
Young Adult
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Summary:Macrophage migration inhibitory factor (MIF) plays an important regulatory role in sepsis. In the promoter region a C/G single nucleotide polymorphism (SNP) at position -173 (rs755622) and a CATT5-8 microsatellite at position -794 are related to modified promoter activity. The purpose of the study was to analyze their association with the incidence and outcome of severe sepsis. Genotype distributions and allele frequencies in 169 patients with severe sepsis, 94 healthy blood donors and 183 postoperative patients without signs of infection or inflammation were analyzed by real time PCR and Sequence analysis. All included individuals were Caucasians. Genotype distribution and allele frequencies of severe sepsis patients were comparable to both control groups. However, the genotype and allele frequencies of both polymorphisms were associated significantly with the outcome of severe sepsis. The highest risk of dying from severe sepsis was detectable in patients carrying a haplotype with the alleles -173 C and CATT7 (p = 0.0005, fisher exact test, RR = 1,806, CI: 1.337 to 2.439). The haplotype with the combination of the -173 C allele and the -794 CATT7 allele may not serve as a marker for susceptibility to sepsis, but may help identify septic patients at risk of dying.
ISSN:1479-5876
1479-5876
DOI:10.1186/1479-5876-7-100