The Potential Role of R4 Regulators of G Protein Signaling (RGS) Proteins in Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is a complex and heterogeneous disease that primarily results from impaired insulin secretion or insulin resistance (IR). G protein-coupled receptors (GPCRs) are proposed as therapeutic targets for T2DM. GPCRs transduce signals via the Gα protein, playing an integral...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-12, Vol.11 (23), p.3897
Main Authors: Zhang, Xiaohong, Lv, Hongyan, Mei, Juan, Ji, Bingyuan, Huang, Shuhong, Li, Xuezhi
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Body fat
Care and treatment
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Diagnosis
G protein-coupled receptors
G proteins
Glucose
GTP-Binding Proteins - metabolism
Health aspects
Humans
Hydrolysis
Immune system
Insulin
Insulin Resistance
Insulin secretion
Kinases
Ligands
Liver
Mammals
Metabolism
Musculoskeletal system
Nervous system
Prevention
Proteins
Receptors, G-Protein-Coupled - metabolism
Regulation
regulators of G protein signaling
Review
RGS Proteins - metabolism
Risk factors
Secretion
Signal Transduction
Therapeutic targets
Type 2 diabetes
type 2 diabetes mellitus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Type 2 diabetes mellitus (T2DM) is a complex and heterogeneous disease that primarily results from impaired insulin secretion or insulin resistance (IR). G protein-coupled receptors (GPCRs) are proposed as therapeutic targets for T2DM. GPCRs transduce signals via the Gα protein, playing an integral role in insulin secretion and IR. The regulators of G protein signaling (RGS) family proteins can bind to Gα proteins and function as GTPase-activating proteins (GAP) to accelerate GTP hydrolysis, thereby terminating Gα protein signaling. Thus, RGS proteins determine the size and duration of cellular responses to GPCR stimulation. RGSs are becoming popular targeting sites for modulating the signaling of GPCRs and related diseases. The R4 subfamily is the largest RGS family. This review will summarize the research progress on the mechanisms of R4 RGS subfamily proteins in insulin secretion and insulin resistance and analyze their potential value in the treatment of T2DM.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11233897