Visualising and quantifying intestinal permeability -where do we stand

Intestinal permeability is getting more and more attention in gastrointestinal research. Although well recognized, its exact role in health and disease is yet to be defined. There are many methods of quantifying intestinal permeability, but most of them fail to deliver tangible information about the...

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Bibliographic Details
Published in:Annals of hepatology 2021-07, Vol.23, p.100266-100266, Article 100266
Main Authors: Rusticeanu, Monica, Zimmer, Vincent, Lammert, Frank
Format: Article
Language:English
Subjects:
CLE
functional imaging
Humans
Intestinal Absorption
intestinal imaging
Intestinal Mucosa - diagnostic imaging
intestinal permeability
liver cirrhosis
Magnetic Resonance Imaging
Microscopy, Confocal
Permeability
Positron-Emission Tomography
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Summary:Intestinal permeability is getting more and more attention in gastrointestinal research. Although well recognized, its exact role in health and disease is yet to be defined. There are many methods of quantifying intestinal permeability, but most of them fail to deliver tangible information about the morphological integrity of the intestinal barrier. In this review we aim to describe imaging options for the assessment of intestinal barrier integrity and their potential relevance for clinical practice. Our focus is on confocal laser endomicroscopy, which is at this time the only method for visualizing not only functional but also morphological aspects of the gut barrier in vivo.
ISSN:1665-2681
2659-5982
DOI:10.1016/j.aohep.2020.09.010