Effect of local anesthesia on pain scale and specimen adequacy in fine-needle aspiration biopsy of thyroid nodules for liquid-based cytology

Fine-needle aspiration biopsy (FNAB) is a routine diagnostic test for thyroid nodules. The use of local anesthesia (LA) before the procedure is still controversial. This prospective study aimed to evaluate the degree of pain and specimen adequacy in liquid-based cytology (LBC) for FNAB of thyroid no...

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Bibliographic Details
Published in:Scientific reports 2022-11, Vol.12 (1), p.18498-18498, Article 18498
Main Authors: Lee, Tsung-Lun, Wei, Pei-Yin, Tai, Shyh-Kuan
Format: Article
Language:English
Subjects:
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Anesthesia
Anesthesia, Local
Biopsy
Biopsy, Fine-Needle - methods
Cellular biology
Cytology
Humanities and Social Sciences
Humans
Local anesthesia
multidisciplinary
Multivariate analysis
Nodules
Pain
Pain - etiology
Prospective Studies
Retrospective Studies
Science
Science (multidisciplinary)
Sensitivity and Specificity
Thyroid
Thyroid gland
Thyroid Neoplasms - pathology
Thyroid Nodule - pathology
Trachea
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Summary:Fine-needle aspiration biopsy (FNAB) is a routine diagnostic test for thyroid nodules. The use of local anesthesia (LA) before the procedure is still controversial. This prospective study aimed to evaluate the degree of pain and specimen adequacy in liquid-based cytology (LBC) for FNAB of thyroid nodules with and without LA. A total of 100 consecutive patients with thyroid nodules who underwent FNAB with and without LA between January and December 2020 were included. Patients who received LA had a significantly lower immediate pain scale score (P = 0.01). Multivariate analysis demonstrated that no use of LA (odds ratio [OR] = 3.48, 95% confidence interval [CI] = 1.50–8.10, P = 0.004) and lesion abutting the trachea (OR = 6.14, 95% CI = 1.56–24.12, P = 0.009) were independently and significantly associated with pain degree immediately after FNAB. A higher proportion of patients who previously underwent FNAB thought that LA was helpful and should be performed prior to FNAB. However, the use of LA did not improve the specimen adequacy (P = 0.075). The results showed that administration of LA with a proper technique before ultrasound-guided FNAB might reduce immediate pain after the procedure, and patients may experience more pain when the aspirated nodules abut the trachea.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-23031-0