A novel prognostic model for hepatocellular carcinoma based on pyruvate metabolism-related genes

Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, accounting for over 90% of cases. As pyruvate metabolic pathways are often dysregulated in cancer cells, investigating pyruvate metabolism-related genes may help identify prognostic gene signature and develop potentia...

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Published in:Scientific reports 2023-06, Vol.13 (1), p.9780-14, Article 9780
Main Authors: Shi, Qingmiao, Xue, Chen, Zeng, Yifan, Gu, Xinyu, Wang, Jinzhi, Li, Lanjuan
Format: Article
Language:English
Subjects:
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Carcinoma, Hepatocellular - genetics
Copy number
DNA Copy Number Variations
Gene expression
Genes
Hepatocellular carcinoma
Humanities and Social Sciences
Humans
Infiltration
Liver cancer
Liver Neoplasms - genetics
Metabolic pathways
Metabolism
multidisciplinary
Mutation
Point mutation
Prognosis
Pyruvic Acid
Science
Science (multidisciplinary)
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Summary:Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, accounting for over 90% of cases. As pyruvate metabolic pathways are often dysregulated in cancer cells, investigating pyruvate metabolism-related genes may help identify prognostic gene signature and develop potential strategies for the management of patients with HCC. The mRNA expression profile, gene mutation data, and clinical information of HCC were obtained from open-source databases. A list of pyruvate metabolism-related genes was downloaded from the MSigDB dataset. Our findings revealed that certain pyruvate metabolism-related genes had copy number variations and single nucleotide variations in patients with liver cancer. Based on pyruvate metabolism-related genes, we stratified patients with HCC into three subtypes with different prognoses, clinical features, mutation profiles, functional annotation, and immune infiltration status. Next, we identified 13 key pyruvate metabolism-related genes significantly correlated with the prognosis of HCC using six machine learning algorithms and constructed a risk model. We also observed that the risk score was positively associated with a worse prognosis and increased immune infiltration. In summary, our study established a prognostic risk model for HCC based on pyruvate metabolism-related genes, which may contribute to the identification of potential prognostic targets and the development of new clinical management strategies for HCC.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-37000-8