In Vivo investigation of radiolabeled Bevacizumab in healthy rat tissues

In this study, BevMab was conjugated with the bifunctional chelating agent [diethylenetriamine pentaacetic acid (DTPA)] and the product (BevMab-DTPA) was labeled with 99mTc using stannous chloride reducing method. The quality control studies of radiolabeled compound (99mTc-BevMab-DTPA) were done wit...

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Bibliographic Details
Published in:Brazilian archives of biology and technology 2011-02, Vol.54 (1), p.73-79
Main Authors: Demir, Ilknur, Muftuler, Fazilet Zumrut Biber, Unak, Perihan, Acar, Cigdem
Format: Article
Language:English
Subjects:
99mTc
Angiogenesis
Bevacizumab
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Summary:In this study, BevMab was conjugated with the bifunctional chelating agent [diethylenetriamine pentaacetic acid (DTPA)] and the product (BevMab-DTPA) was labeled with 99mTc using stannous chloride reducing method. The quality control studies of radiolabeled compound (99mTc-BevMab-DTPA) were done with Thin Layer Radio Chromatography (TLRC) and High Performance Liquid Radio Chromatography (HPLRC) methods (% 95
ISSN:1516-8913
1516-8913
1678-4324
DOI:10.1590/S1516-89132011000100010