Mesenchymal stem cell-based therapy for radiation-induced lung injury

Since radiotherapy is widely used in managing thoracic tumors, physicians have begun to realize that radiation-induced lung injury (RILI) seriously limits the effects of radiotherapy. Unfortunately, there are still no effective methods for controlling RILI. Over the last few decades numerous studies...

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Bibliographic Details
Published in:Stem cell research & therapy 2018-01, Vol.9 (1), p.18-18, Article 18
Main Authors: Xu, Tiankai, Zhang, Yuyu, Chang, Pengyu, Gong, Shouliang, Shao, Lihong, Dong, Lihua
Format: Article
Language:English
Subjects:
Alveolar Epithelial Cells - cytology
Animals
Care and treatment
Cell- and Tissue-Based Therapy - methods
Cellular therapy
Humans
Lung diseases
Lung Injury - therapy
Lung Neoplasms - radiotherapy
Mesenchymal Stem Cell Transplantation
Mesenchymal stem cells (MSCs)
Mesenchymal Stem Cells - cytology
Mice
Radiation Injuries - therapy
Radiation-induced lung injury (RILI)
Radiotherapy - adverse effects
Rats
Regeneration - physiology
Review
Stem cell therapy
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Summary:Since radiotherapy is widely used in managing thoracic tumors, physicians have begun to realize that radiation-induced lung injury (RILI) seriously limits the effects of radiotherapy. Unfortunately, there are still no effective methods for controlling RILI. Over the last few decades numerous studies have reported the beneficial effects of mesenchymal stem cells (MSCs) on tissue repair and regeneration. MSCs can not only differentiate into lung alveolar epithelial cells and secrete anti-inflammatory factors, but they also deliver some vehicles for gene therapy in repairing the injured lung, which provides new ideas for managing RILI. Thus, many scientists have attempted to manage RILI using MSC-based therapy. However, as a novel therapy MSCs still face various limitations. Herein, we shed light on the current understanding of MSC-based therapy for RILI, including the feasibility, molecular mechanisms, animal studies, and clinical research of MSC-based therapy for RILI. We also present an overview of RILI and MSCs.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-018-0776-6