Micro-/Nano-Scales Direct Cell Behavior on Biomaterial Surfaces

Cells are the smallest living units of a human body's structure and function, and their behaviors should not be ignored in human physiological and pathological metabolic activities. Each cell has a different scale, and presents distinct responses to specific scales: Vascular endothelial cells m...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2018-12, Vol.24 (1), p.75
Main Authors: Wang, Shuo, Li, Jingan, Zhou, Zixiao, Zhou, Sheng, Hu, Zhenqing
Format: Article
Language:English
Subjects:
Behavior
Biocompatibility
Biomaterials
biomaterials surface
Biomedical materials
Cell adhesion & migration
cell behavior
Endothelial cells
Experiments
Fibroblasts
Hydroxyapatite
Lasers
micro/nano scales
Morphology
Nanoparticles
Nanotechnology
Polyethylene terephthalate
Proteins
Review
Stem cells
Structure-function relationships
surface functionalization
Tissue engineering
Topography
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Summary:Cells are the smallest living units of a human body's structure and function, and their behaviors should not be ignored in human physiological and pathological metabolic activities. Each cell has a different scale, and presents distinct responses to specific scales: Vascular endothelial cells may obtain a normal function when regulated by the 25 µm strips, but de-function if the scale is removed; stem cells can rapidly proliferate on the 30 nm scales nanotubes surface, but stop proliferating when the scale is changed to 100 nm. Therefore, micro and nano scales play a crucial role in directing cell behaviors on biomaterials surface. In recent years, a series of biomaterials surface with micro and/or nano scales, such as micro-patterns, nanotubes and nanoparticles, have been developed to control the target cell behavior, and further enhance the surface biocompatibility. This contribution will introduce the related research, and review the advances in the micro/nano scales for biomaterials surface functionalization.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24010075