Circular RNAs in organ injury: recent development

Circular ribonucleic acids (circRNAs) are a class of long non-coding RNA that were once regarded as non-functional transcription byproducts. However, recent studies suggested that circRNAs may exhibit important regulatory roles in many critical biological pathways and disease pathologies. These stud...

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Bibliographic Details
Published in:Journal of translational medicine 2022-11, Vol.20 (1), p.533-533, Article 533
Main Authors: Wong, Ryan, Zhang, Yiwen, Zhao, Hailin, Ma, Daqing
Format: Article
Language:English
Subjects:
Adenosine
Apoptosis
Cell cycle
Cell division
Cell growth
circRNA
Complications and side effects
Cyclin-dependent kinases
Development and progression
Diseases
Gene expression
Gene expression regulation
Genetic aspects
Genomes
Health aspects
High-Throughput Nucleotide Sequencing
Injuries
Kinases
MicroRNAs
miRNA sponge
Organ injury
Physiological aspects
Prospective Studies
Proteins
Review
RNA
RNA - genetics
RNA - metabolism
RNA, Circular - genetics
United Kingdom
Wounds and injuries
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Summary:Circular ribonucleic acids (circRNAs) are a class of long non-coding RNA that were once regarded as non-functional transcription byproducts. However, recent studies suggested that circRNAs may exhibit important regulatory roles in many critical biological pathways and disease pathologies. These studies have identified significantly differential expression profiles of circRNAs upon changes in physiological and pathological conditions of eukaryotic cells. Importantly, a substantial number of studies have suggested that circRNAs may play critical roles in organ injuries. This review aims to provide a summary of recent studies on circRNAs in organ injuries with respect to (1) changes in circRNAs expression patterns, (2) main mechanism axi(e)s, (3) therapeutic implications and (4) future study prospective. With the increasing attention to this research area and the advancement in high-throughput nucleic acid sequencing techniques, our knowledge of circRNAs may bring fruitful outcomes from basic and clinical research.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-022-03725-9