Mannose-binding lectin gene sequence data in Kelantan population

The human mannose-binding lectin ( MBL ) gene encodes a polymorphic protein that plays a crucial role in the innate immune response. Human MBL deficiency is associated with immunodeficiencies, and its variants have been linked to autoimmune and infectious diseases. Despite this significance, gene st...

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Bibliographic Details
Published in:Scientific data 2024-04, Vol.11 (1), p.435-6, Article 435
Main Authors: Zahidin, Muhamad Aidil, Mohd Noor, Noor Haslina, Johan, Muhammad Farid, Abdullah, Abu Dzarr, Zulkafli, Zefarina, Edinur, Hisham Atan
Format: Article
Language:English
Subjects:
692/308/2056
692/53/2421
Alleles
Base Sequence
Data Descriptor
DNA sequencing
Genotyping
Haplotypes
Humanities and Social Sciences
Humans
Immune response
Infectious diseases
Innate immunity
Lectins
Malaysia
Mannose
Mannose-binding lectin
Mannose-Binding Lectin - genetics
multidisciplinary
Mutation
Polymorphism
Population
Proteins
Science
Science (multidisciplinary)
Tuberculosis
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Description
Summary:The human mannose-binding lectin ( MBL ) gene encodes a polymorphic protein that plays a crucial role in the innate immune response. Human MBL deficiency is associated with immunodeficiencies, and its variants have been linked to autoimmune and infectious diseases. Despite this significance, gene studies concerning MBL sequencing are uncommon in Malaysia. Therefore, we aimed to preliminary described the human MBL sequencing dataset based on the Kelantan population. Blood samples were collected from 30 unrelated individuals and underwent DNA extraction, genotyping, and sequencing. The sequencing data generated 886 bp, which were deposited in GenBank (ON619541-ON619546). Allelic variants were identified and translated into six MBL haplotypes: HYPA, HYPB, LYPB, LXPB, HXPA, and LXPA. An evolutionary tree was constructed using the haplotype sequences. These findings contribute to the expansion of MBL information within the country, providing a valuable baseline for future research exploring the association between the gene and targeted diseases.
ISSN:2052-4463
2052-4463
DOI:10.1038/s41597-024-03274-4