Fatty liver index is an independent risk factor for all-cause mortality and major cardiovascular events in type 1 diabetes: an 11-year observational study

Non-alcoholic fatty liver disease (NAFLD), identified by the Fatty Liver Index (FLI), is associated with increased mortality and cardiovascular (CV) outcomes. Whether this also applies to type 1 diabetes (T1D) has not been yet reported. We prospectively observed 774 subjects with type 1 diabetes (ma...

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Published in:Cardiovascular diabetology 2024-02, Vol.23 (1), p.85-85, Article 85
Main Authors: Garofolo, Monia, Lucchesi, Daniela, Giambalvo, Massimo, Aragona, Michele, Bertolotto, Alessandra, Campi, Fabrizio, Bianchi, Cristina, Francesconi, Paolo, Marchetti, Piero, Del Prato, Stefano, Penno, Giuseppe
Format: Article
Language:English
Subjects:
Adult
Albuminuria - complications
Albuminuria - diagnosis
Albuminuria - epidemiology
Alcohol
Amputation
Blood pressure
Body mass index
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - complications
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular outcomes
Cholesterol
Confounding (Statistics)
Creatinine
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 1 - epidemiology
Fatty liver
Fatty liver index
Glycated Hemoglobin
Health risks
Heart attacks
High density lipoprotein
Humans
Hypertension
Insulin resistance
Liver cirrhosis
Liver diseases
Low density lipoprotein
Male
Metabolism
Mortality
NAFLD
Non-alcoholic Fatty Liver Disease - epidemiology
Observational studies
Prospective Studies
Regression analysis
Risk Factors
Stroke
Triglycerides
Type 1 diabetes
Young Adult
γ-Glutamyltransferase
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Summary:Non-alcoholic fatty liver disease (NAFLD), identified by the Fatty Liver Index (FLI), is associated with increased mortality and cardiovascular (CV) outcomes. Whether this also applies to type 1 diabetes (T1D) has not been yet reported. We prospectively observed 774 subjects with type 1 diabetes (males 52%, 30.3 ± 11.1 years old, diabetes duration (DD) 18.5 ± 11.6 years, HbA1c 7.8 ± 1.2%) to assess the associations between FLI (based on BMI, waist circumference, gamma-glutamyl transferase and triglycerides) and all-cause death and first CV events. Over a median 11-year follow-up, 57 subjects died (7.4%) and 49 CV events (6.7%) occurred among 736 individuals with retrievable incidence data. At baseline, FLI was 
ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-024-02171-9