Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) is one of the malignant tumors with a poor prognosis. Periodontitis (PD is considered a high-risk factor for OSCC, but the genetic mechanism is rarely studied. This study aims to link OSCC and PD by identifying common differentially expressed miRNAs (Co-DEmiRNAs),...

Full description

Saved in:
Bibliographic Details
Published in:BMC oral health 2023-01, Vol.23 (1), p.19-15, Article 19
Main Authors: Li, Zhengrui, Fu, Rao, Wen, Xutao, Zhang, Ling
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Complications and side effects
Diagnosis
DNA binding proteins
Gene expression
Gene Expression Profiling
Genetic aspects
Genetic crosstalk
Humans
MicroRNA
MicroRNAs - genetics
Mouth cancer
Mouth Neoplasms - genetics
Network analysis
Oral squamous cell carcinoma
Periodontitis
Periodontitis - genetics
Squamous Cell Carcinoma of Head and Neck - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oral squamous cell carcinoma (OSCC) is one of the malignant tumors with a poor prognosis. Periodontitis (PD is considered a high-risk factor for OSCC, but the genetic mechanism is rarely studied. This study aims to link OSCC and PD by identifying common differentially expressed miRNAs (Co-DEmiRNAs), their related genes (Hub genes), transcription factors (TFs), signaling pathways, enrichment functions, and compounds, and searching for genetic commonalities. The miRNAs expression datasets of OSCC and PD were searched from the GEO database. The miRNA and related crosstalk mechanism between OSCC and PD was obtained through a series of analyses. hsa-mir-497, hsa-mir-224, hsa-mir-210, hsa-mir-29c, hsa-mir-486-5p, and hsa-mir-31are the top miRNA nodes in Co-DEmiRNA-Target networks. The most significant candidate miRNA dysregulation genes are ZNF460, FBN1, CDK6, BTG2, and CBX6, while the most important dysregulation TF includes HIF1A, TP53, E2F1, MYCN, and JUN. 5-fluorouracil, Ginsenoside, Rh2, and Formaldehyde are the most correlated compounds. Enrichment analysis revealed cancer-related pathways and so on. The comprehensive analysis reveals the interacting genetic and molecular mechanism between OSCC and PD, linking both and providing a foundation for future basic and clinical research.
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-022-02704-2