Red Lentil Extract: Neuroprotective Effects on Perphenazine Induced Catatonia in Rats

Parkinsonism is a neurodegenerative disease that is defined by certain symptoms such as muscle rigidity, impaired movement, catatonia, tremor and disorientation of body. The aim was to investigate the effect of red lentil extract on perphenazine-induced Catatonia in model of rat. This experimental s...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2016-06, Vol.10 (6), p.FF05-FF08
Main Authors: Houshmand, Gholamreza, Tarahomi, Shahram, Arzi, Ardeshir, Goudarzi, Mehdi, Bahadoram, Mohammad, Rashidi-Nooshabadi, Mohammadreza
Format: Article
Language:English
Subjects:
antioxidants
leguminoseae
muscle rigidity
parkinsonian disorders
Pharmacology Section
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Summary:Parkinsonism is a neurodegenerative disease that is defined by certain symptoms such as muscle rigidity, impaired movement, catatonia, tremor and disorientation of body. The aim was to investigate the effect of red lentil extract on perphenazine-induced Catatonia in model of rat. This experimental study was done on 48 male albino rats (weight 180-200g) of the Sprague-Dawley strain. Animals were randomly divided into six groups and were pre-treated with a single dose of red lentil extract (200, 400, 800 and 1000 mg/kg), most effective dose of bromocriptine (30mg/kg) and normal saline (5ml/kg) via intraperitoneal (IP) route. perphenazine (5 mg/kg) was after 30 minutes, administered (IP) to induce catatonia. The scoring method of Morpurgo was used to determine the muscular rigidity of animals. The results showed that the 200mg/kg red lentil extract treated group had no significant reduction in catatonic responses after perphenazine administration in comparison with control group while the groups that received 800 and 1000mg/kg of red lentil extract showed significant difference (p
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2016/17813.7977