Radiochemotherapy in Pancreatic Cancer

Despite the advancements made in oncology in recent years, the treatment of pancreatic cancer remains a challenge. Five-year survival rates for this cancer do not exceed 10%. Among the reasons contributing to poor treatment outcomes are the oligosymptomatic course of the tumor, diagnostic difficulti...

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Bibliographic Details
Published in:Current oncology (Toronto) 2024-06, Vol.31 (6), p.3291-3300
Main Authors: Domagała-Haduch, Małgorzata, Gorzelak-Magiera, Anita, Michalecki, Łukasz, Gisterek-Grocholska, Iwona
Format: Article
Language:English
Subjects:
Adjuvant treatment
borderline resectable pancreatic cancer
Cancer
Care and treatment
Chemoradiotherapy - methods
chemotherapy
Humans
Metastasis
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - radiotherapy
Pancreatic Neoplasms - therapy
radiochemotherapy
Radiotherapy
resectable pancreatic cancer
Review
unresectable pancreatic cancer
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Summary:Despite the advancements made in oncology in recent years, the treatment of pancreatic cancer remains a challenge. Five-year survival rates for this cancer do not exceed 10%. Among the reasons contributing to poor treatment outcomes are the oligosymptomatic course of the tumor, diagnostic difficulties due to the anatomical location of the organ, and the unique biological features of pancreatic cancer. The mainstay of treatment for resectable cancer is surgery and adjuvant chemotherapy. For unresectable and metastatic cancers, chemotherapy remains the primary method of treatment. At the same time, for about thirty years, there have been attempts to improve treatment outcomes by using radiotherapy combined with systemic treatment. Unlike chemotherapy, radiotherapy has no established place in the treatment of pancreatic cancer. This paper addresses the topic of radiotherapy in pancreatic cancer as a valuable method that can improve treatment outcomes alongside chemotherapy.
ISSN:1198-0052
1718-7729
1718-7729
DOI:10.3390/curroncol31060250