Plasticity and modular control of locomotor patterns in neurological disorders with motor deficits

Human locomotor movements exhibit considerable variability and are highly complex in terms of both neural activation and biomechanical output. The building blocks with which the central nervous system constructs these motor patterns can be preserved in patients with various sensory-motor disorders....

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Bibliographic Details
Published in:Frontiers in computational neuroscience 2013-09, Vol.7, p.123-123
Main Authors: Ivanenko, Y P, Cappellini, G, Solopova, I A, Grishin, A A, Maclellan, M J, Poppele, R E, Lacquaniti, F
Format: Article
Language:English
Subjects:
Amputation
Ankle
Biomechanics
Brain damage
Central nervous system
Compensation
EMG activity
Fitness equipment
Gait
Legs
modularity
Movement disorders
Muscle function
Neurological diseases
Neurological disorders
Neuroscience
Neurosciences
Patients
Peripheral neuropathy
plantarflexor weakness
Spinal cord injuries
spinal cord injury
Spinal plasticity
Stroke
Training
Walking
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Summary:Human locomotor movements exhibit considerable variability and are highly complex in terms of both neural activation and biomechanical output. The building blocks with which the central nervous system constructs these motor patterns can be preserved in patients with various sensory-motor disorders. In particular, several studies highlighted a modular burst-like organization of the muscle activity. Here we review and discuss this issue with a particular emphasis on the various examples of adaptation of locomotor patterns in patients (with large fiber neuropathy, amputees, stroke and spinal cord injury). The results highlight plasticity and different solutions to reorganize muscle patterns in both peripheral and central nervous system lesions. The findings are discussed in a general context of compensatory gait mechanisms, spatiotemporal architecture and modularity of the locomotor program.
ISSN:1662-5188
1662-5188
DOI:10.3389/fncom.2013.00123