Lipid profiling in maternal and fetal circulations in preeclampsia and fetal growth restriction-a prospective case control observational study

While many risk factors for preeclampsia, such as increased body mass index, advanced maternal age, chronic hypertension, diabetes, are now established in clinical practice, maternal lipid profile has not been included in the risk assessment for preeclampsia. We aim to characterize the serum levels...

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Bibliographic Details
Published in:BMC pregnancy and childbirth 2020-01, Vol.20 (1), p.61-61, Article 61
Main Authors: Alahakoon, Thushari I, Medbury, Heather J, Williams, Helen, Lee, Vincent W
Format: Article
Language:English
Subjects:
Apolipoprotein
Cardiovascular disease
Fetal growth restriction
Fetal lipids
Fetuses
Growth disorders
Health risk assessment
Lipids
Maternal & child health
Maternal lipids
Observational studies
Preeclampsia
Prenatal development
Womens health
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Summary:While many risk factors for preeclampsia, such as increased body mass index, advanced maternal age, chronic hypertension, diabetes, are now established in clinical practice, maternal lipid profile has not been included in the risk assessment for preeclampsia. We aim to characterize the serum levels of Total Cholesterol (TC), High density lipoprotein (HDL), Low density lipoprotein (LDL), Triglycerides (TG), Apolipoprotein A1, Apolipoprotein B and their ratios TC/HDL and ApoB/ApoA1 in the maternal and fetal circulations of normal pregnancy, preeclampsia (PE), fetal growth restriction (FGR) and PE + FGR. A prospective cross-sectional case control study was conducted measuring maternal and fetal lipid levels by enzymatic analysis and immune-turbidimetric enzymatic assays. FGR was defined by elevated umbilical artery Doppler resistance in association with estimated fetal weight 
ISSN:1471-2393
1471-2393
DOI:10.1186/s12884-020-2753-1