Exploration of Predictive Biomarkers for Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps Based on Serum Multiple-Cytokine Profiling

Background. Functional nasal endoscopic surgery (FESS) is an effective treatment approach for chronic rhinosinusitis with nasal polyps (CRSwNP) patients, but some patients still suffer from postoperative recurrence. This study is aimed at investigating the expression of multiple cytokines in CRSwNP...

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Bibliographic Details
Published in:Mediators of inflammation 2022-09, Vol.2022, p.1-11
Main Authors: Wang, Gang, Zheng, Huiyuan, Chen, Xiaoqian, Zheng, Jing, Zhan, Jiabin, Li, Rui, Qi, Yanyan, Ye, Yi, Zeng, Min, Wei, Xin
Format: Article
Language:English
Subjects:
Analysis
B cells
Biological markers
Biomarkers
Body mass index
Care and treatment
Chemokines
Cytokines
Endoscopy
Eotaxin
Granulocyte colony-stimulating factor
Granulocytes
Interferon
Interleukin 13
Interleukin 5
Monocyte chemoattractant protein 1
Nasal polyps
Patients
Polyps
Proteins
RANTES
Rhinitis
Rhinosinusitis
Serum levels
Sinusitis
Tomography
Tumor necrosis factor-TNF
Variables
α-Interferon
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Summary:Background. Functional nasal endoscopic surgery (FESS) is an effective treatment approach for chronic rhinosinusitis with nasal polyps (CRSwNP) patients, but some patients still suffer from postoperative recurrence. This study is aimed at investigating the expression of multiple cytokines in CRSwNP and revealing their relationships with postoperative recurrence. Methods. A total of 72 patients with CRSwNP, including 36 primary and 36 recurrent patients, were enrolled. Serum samples were obtained, 30 cytokine levels were measured by multiplex analysis, and the association between cytokine levels and recurrence was assessed. The most potential cytokines were further validated in another independent cohort with 60 primary and 60 recurrent CRSwNP patients. Results. The results of multiple cytokine profiling exhibited that the levels of eotaxin, G-CSF, IFN-α, IL-13, IL-17A, IL-5, MCP-1, and RANTES were vastly changed in the recurrent group in comparison with the primary group. Receiver-operating characteristic (ROC) curves highlighted that serum levels of eotaxin, IL-17A, and RANTES were strongly predictive of postoperative recurrence (area under the curve AUC>0.7, P
ISSN:0962-9351
1466-1861
DOI:10.1155/2022/1061658