The Quality of Recovery after Dexamethasone, Ondansetron, or Placebo Administration in Patients Undergoing Lower Limbs Orthopedic Surgery under Spinal Anesthesia Using Intrathecal Morphine. A Randomized Controlled Trial

Intrathecal morphine is widely and successfully used to prevent postoperative pain after orthopedic surgery, but it is frequently associated with side effects. The aim of this study was to evaluate the effect of dexamethasone or ondansetron when compared to placebo to reduce the occurrence of these...

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Bibliographic Details
Published in:Anesthesiology research and practice 2020, Vol.2020 (2020), p.1-6
Main Authors: Bloomstone, Joshua, Calil, Samira Joverno, Vargas, Roberta Costa, Gonçalves, Renyer dos Santos, Ferreira, Miguel Antônio Teixeira, Moro, Eduardo Toshiyuki, Soranz, Maria Alice
Format: Article
Language:English
Subjects:
Anesthesia
Bupivacaine
Central nervous system depressants
Clinical Study
Comparative analysis
Dexamethasone
Morphine
Nalbuphine
Ondansetron
Orthopedic surgery
Palonosetron
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Summary:Intrathecal morphine is widely and successfully used to prevent postoperative pain after orthopedic surgery, but it is frequently associated with side effects. The aim of this study was to evaluate the effect of dexamethasone or ondansetron when compared to placebo to reduce the occurrence of these undesirable effects and, consequently, to improve the quality of recovery based on patient’s perspective. Methods. One hundred and thirty-five patients undergoing lower extremity orthopedic surgery under spinal anesthesia using bupivacaine and morphine were randomly assigned to receive IV dexamethasone, ondansetron, or saline. On the morning following surgery, a quality of recovery questionnaire (QoR-40) was completed. Results. No differences were detected in the global and dimensional QoR-40 scores following surgery; however, following postanesthesia care unit (PACU) discharge, pain scores were higher in patients receiving ondansetron compared with patients who received dexamethasone. Conclusion. Neither ondansetron nor dexamethasone improves the quality of recovery after lower limbs orthopedic surgery under spinal anesthesia using intrathecal morphine.
ISSN:1687-6962
1687-6970
DOI:10.1155/2020/9265698