Reduced Levels of miR-342-5p in Plasma Are Associated With Worse Cognitive Evolution in Patients With Mild Alzheimer's Disease

Progressive cognitive decline is the most relevant clinical symptom of Alzheimer's disease (AD). However, the rate of cognitive decline is highly variable between patients. Synaptic deficits are the neuropathological event most correlated with cognitive impairment in AD. Considering the importa...

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Published in:Frontiers in aging neuroscience 2021-08, Vol.13, p.705989-705989
Main Authors: Dakterzada, Farida, David Benítez, Iván, Targa, Adriano, Lladó, Albert, Torres, Gerard, Romero, Leila, de Gonzalo-Calvo, David, Moncusí-Moix, Anna, Tort-Merino, Adria, Huerto, Raquel, Sánchez-de-la-Torre, Manuel, Barbé, Ferran, Piñol-Ripoll, Gerard
Format: Article
Language:English
Subjects:
Alzheimer's disease
Binding sites
biomarker
Biomarkers
Cognition & reasoning
Cognitive ability
cognitive decline
Hospitals
Memory
MicroRNAs
miR-342-5p
miRNA
Neurodegenerative diseases
Neuropathology
Neuroscience
Patients
Plasma
Proteins
Questionnaires
Synaptic plasticity
Womens health
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Summary:Progressive cognitive decline is the most relevant clinical symptom of Alzheimer's disease (AD). However, the rate of cognitive decline is highly variable between patients. Synaptic deficits are the neuropathological event most correlated with cognitive impairment in AD. Considering the important role of microRNAs (miRNAs) in regulating synaptic plasticity, our objective was to identify the plasma miRNAs associated with the rate of cognitive decline in patients with mild AD. We analyzed 754 plasma miRNAs from 19 women diagnosed with mild AD using TaqMan low-density array cards. The patients were grouped based on the rate of decline in the MMSE score after 2 years [
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2021.705989