Clinical benefits of deep inspiration breath-hold in postoperative radiotherapy for right-sided breast cancer: a meta-analysis

The study aims to emphasize the clinical importance of the Deep Inspiration Breath Hold (DIBH) technique by quantifying its dosimetric advantages over Free Breathing (FB) in reducing radiation exposure to the heart, liver, and lungs for right-sided breast cancer patients. This evidence supports its...

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Bibliographic Details
Published in:BMC cancer 2024-10, Vol.24 (1), p.1238-8, Article 1238
Main Authors: Li, Zhuocheng, Jian, Chenxi, Li, Yuanyuan, Pan, Zhenyu, Yang, Guozi, Sun, Xingru
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms - radiotherapy
Breast Neoplasms - surgery
Breath Holding
Cancer therapies
Care and treatment
Clinical trials
Deep inspiration breath hold
Demographic aspects
Diagnosis
Female
Heart
Heart - radiation effects
Hormone therapy
Humans
Inhalation
Liver
Liver - radiation effects
Liver - surgery
Liver cancer
Lung - radiation effects
Lung - surgery
Lung cancer
Meta-analysis
Mortality
Organs at Risk - radiation effects
Patient outcomes
Radiation therapy
Radiotherapy
Radiotherapy Dosage
Radiotherapy, Adjuvant - adverse effects
Radiotherapy, Adjuvant - methods
Statistical significance
Systematic Review
Toxicity
Unilateral Breast Neoplasms - radiotherapy
Unilateral Breast Neoplasms - surgery
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Summary:The study aims to emphasize the clinical importance of the Deep Inspiration Breath Hold (DIBH) technique by quantifying its dosimetric advantages over Free Breathing (FB) in reducing radiation exposure to the heart, liver, and lungs for right-sided breast cancer patients. This evidence supports its potential for routine clinical use to mitigate radiation-induced toxicity. A systematic retrieval of controlled trials comparing DIBH and FB techniques in postoperative radiotherapy for right-sided breast cancer was conducted utilizing the PubMed, Embase, Cochrane Library, and Web of Science databases. The primary outcomes assessed included the doses of adjacent normal tissues (heart, liver, and lungs). Summary standardized mean differences (SMD) along with 95% confidence intervals (CI) were computed, respectively. StataMP 17 software was selected to perform data analysis. The study encompassed an analysis of 313 patients derived from seven online studies, comprising 168 individuals in the DIBH group and 269 individuals in the FB group. The findings indicated that the DIBH group received significantly lower irradiation doses to the heart, liver, and lungs in comparison to the FB group, with statistical significance (heart dose: SMD = -0.63, 95% CI -0.85 to -0.41, P 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-024-12992-2