Comparative Evaluation of the Chemical Components and Anti-Inflammatory Potential of Yellow- and Blue-Flowered Meconopsis Species: M. integrifolia and M. betonicifolia

has long been used in traditional Tibetan medicine to treat various inflammatory and pain-related conditions. However, blue-flowered ( ) is becoming increasingly scarce due to overharvesting. As a potential alternative, yellow-flowered ( ) shows promise but requires comprehensive characterization. T...

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Bibliographic Details
Published in:Metabolites 2024-10, Vol.14 (10), p.563
Main Authors: Cheng, Peizhao, Gan, Ruixi, Wang, Cong, Xu, Qian, Norbu, Kelsang, Zhou, Feng, Kong, Sixin, Jia, Zhuoma, Jiabu, Dawa, Feng, Xin, Wang, Junsong
Format: Article
Language:English
Subjects:
anti-inflammation
Anti-inflammatory drugs
Biodiversity
Ethanol
Health aspects
Herbal medicine
Identification and classification
Inflammation
Liquid chromatography
Macrophages
Mass spectroscopy
Measurement
Meconopsis
Meconopsis betonicifolia
Meconopsis integrifolia
Medicine
Metabolic pathways
Metabolism
Metabolites
Metabolomics
Nitric oxide
Physiological aspects
Solvents
traditional Tibetan medicine
Ultrasonic imaging
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Summary:has long been used in traditional Tibetan medicine to treat various inflammatory and pain-related conditions. However, blue-flowered ( ) is becoming increasingly scarce due to overharvesting. As a potential alternative, yellow-flowered ( ) shows promise but requires comprehensive characterization. This study aimed to evaluate and compare the anti-inflammatory potential of yellow- and blue-flowered species. Liquid chromatography-mass spectrometry (LC-MS) techniques were used to analyze the chemical profiles of yellow- and blue-flowered . Putative targets of shared constituents were subjected to GO and disease enrichment analysis. The LPS-induced RAW264.7 macrophage model was employed to assess anti-inflammatory effects. Metabolomics was applied to gain mechanistic insights. LC-MS revealed over 70% chemical similarity between species. Enrichment analysis associated targets with inflammation-related pathways. In macrophage assays, both species demonstrated dose-dependent antioxidative and anti-inflammatory activities, with yellow exhibiting superior efficacy. Metabolomics showed modulation of key inflammatory metabolic pathways. This integrative study validated yellow-flowered as a credible alternative to its blue-flowered counterpart for anti-inflammatory applications. Metabolic profiling provided initial clues regarding their multi-targeted modes of action, highlighting their potential for sustainable utilization and biodiversity conservation.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo14100563