Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability

Flavonoids are a group of secondary metabolites derived from plant-based foods, and they offer many health benefits in different stages of several diseases. This review will focus on their effects on ion channels expressed in vascular smooth muscle during atherosclerosis. Since ion channels can be r...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2021-06, Vol.26 (12), p.3557
Main Authors: Grijalva-Guiza, Rosa Edith, Jiménez-Garduño, Aura Matilde, Hernández, Luis Ricardo
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Arteriosclerosis
Atherosclerosis
Atherosclerosis - drug therapy
Atherosclerosis - metabolism
Calcification
Channel gating
Cholesterol
Disease prevention
Disease Progression
Electrode potentials
Endothelium
Extracellular matrix
Fatty acids
Flavonoids
Flavonoids - pharmacology
Fruits
Humans
Hypotheses
Inflammation
Ion channels
Ion Channels - metabolism
Lipids
Lipoproteins
Lymphocytes
Metabolism
Metabolites
Mortality
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - metabolism
Muscles
Myocytes, Smooth Muscle - drug effects
Myocytes, Smooth Muscle - metabolism
Oxidation
Oxidation-Reduction - drug effects
Oxidative stress
Permeability
Plant-based foods
Polyphenols
progression
Proteins
Redox potential
Retention
Review
Secondary metabolites
Smooth muscle
vascular
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creator Grijalva-Guiza, Rosa Edith
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description Flavonoids are a group of secondary metabolites derived from plant-based foods, and they offer many health benefits in different stages of several diseases. This review will focus on their effects on ion channels expressed in vascular smooth muscle during atherosclerosis. Since ion channels can be regulated by redox potential, it is expected that during the onset of oxidative stress-related diseases, ion channels present changes in their conductive activity, impacting the progression of the disease. A typical oxidative stress-related condition is atherosclerosis, which involves the dysfunction of vascular smooth muscle. We aim to present the state of the art on how redox potential affects vascular smooth muscle ion channel function and summarize if the benefits observed in this disease by using flavonoids involve restoring the ion channel activity.
doi_str_mv 10.3390/molecules26123557
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subjects Animals
Antioxidants
Arteriosclerosis
Atherosclerosis
Atherosclerosis - drug therapy
Atherosclerosis - metabolism
Calcification
Channel gating
Cholesterol
Disease prevention
Disease Progression
Electrode potentials
Endothelium
Extracellular matrix
Fatty acids
Flavonoids
Flavonoids - pharmacology
Fruits
Humans
Hypotheses
Inflammation
Ion channels
Ion Channels - metabolism
Lipids
Lipoproteins
Lymphocytes
Metabolism
Metabolites
Mortality
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - metabolism
Muscles
Myocytes, Smooth Muscle - drug effects
Myocytes, Smooth Muscle - metabolism
Oxidation
Oxidation-Reduction - drug effects
Oxidative stress
Permeability
Plant-based foods
Polyphenols
progression
Proteins
Redox potential
Retention
Review
Secondary metabolites
Smooth muscle
vascular
title Potential Benefits of Flavonoids on the Progression of Atherosclerosis by Their Effect on Vascular Smooth Muscle Excitability
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