Protein homeostasis in aging and cancer

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can impr...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2023-02, Vol.11, p.1143532-1143532
Main Authors: Chen, Xiao-Qiong, Shen, Tao, Fang, Shao-Jun, Sun, Xiao-Min, Li, Guo-Yu, Li, Yun-Feng
Format: Article
Language:English
Subjects:
aging
autophagy-lysosomal system
cancer
Cell and Developmental Biology
molecular chaperones
protein homeostasis
ubiquitin-proteasome system
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Summary:Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals. In this review, we summarize the regulatory mechanisms of proteostasis and discuss the relationship between proteostasis and aging and age-related diseases, including cancer. Furthermore, we highlight the clinical application value of proteostasis maintenance in delaying the aging process and promoting long-term health.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2023.1143532