Significant association of BDNF rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis

Previously published articles have suggested that rs6265 G>A polymorphism is a potential risk factor for epilepsy. However, the results were not consistent. We conducted a meta-analysis to explore the association between rs6265 G>A polymorphism and epilepsy risk. Four online databases were sea...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2018-01, Vol.14, p.1035-1046
Main Authors: Xu, Yue-Long, Li, Xiu-Xiu, Zhuang, Su-Jing, Guo, Shi-Feng, Xiang, Jian-Ping, Wang, Long, Zhou, Lan, Wu, Bin
Format: Article
Language:English
Subjects:
Age
Alzheimer's disease
Brain Derived Neurotrophic Factor
Brain research
Convulsions & seizures
Developing countries
Epilepsy
Hospitals
LDCs
Meta-analysis
Mutation
Nervous system
Neurology
Original Research
Polymorphism
Studies
Systematic review
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Summary:Previously published articles have suggested that rs6265 G>A polymorphism is a potential risk factor for epilepsy. However, the results were not consistent. We conducted a meta-analysis to explore the association between rs6265 G>A polymorphism and epilepsy risk. Four online databases were searched, and related studies were reviewed from their inception up to June 20, 2017. ORs and corresponding 95% CIs were used to calculate the associations of each genetic model. Overall, 10 case-control publications involving 9,512 subjects were included in this meta-analysis. Significant associations were found between rs6265 G>A polymorphism and epilepsy (A vs G: OR=0.88, 95% CI=0.83-0.94,
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S154927