Clinical and Mechanistic Implications of R-Loops in Human Leukemias

Genetic mutations or environmental agents are major contributors to leukemia and are associated with genomic instability. R-loops are three-stranded nucleic acid structures consisting of an RNA-DNA hybrid and a non-template single-stranded DNA. These structures regulate various cellular processes, i...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-03, Vol.24 (6), p.5966
Main Authors: Lee, Seo-Yun, Miller, Kyle M, Kim, Jae-Jin
Format: Article
Language:English
Subjects:
B cells
Cancer
Cellular structure
Deoxyribonucleic acid
DNA
DNA damage
DNA methylation
DNA Repair
DNA Replication
Double-strand break repair
Gene mutations
Genes
Genetic aspects
Genetic transcription
genome instability
Genomes
Genomic Instability
Health aspects
Homeostasis
Humans
Leukemia
Leukemia - genetics
Medical prognosis
Mitochondrial DNA
Mutation
Nucleic acids
Proteins
R-loop
R-Loop Structures
R-loops
Review
RNA
RNA - genetics
RNA polymerase
Single-stranded DNA
Stem cells
Therapeutic targets
transcription
Transcription, Genetic
Tumorigenesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genetic mutations or environmental agents are major contributors to leukemia and are associated with genomic instability. R-loops are three-stranded nucleic acid structures consisting of an RNA-DNA hybrid and a non-template single-stranded DNA. These structures regulate various cellular processes, including transcription, replication, and DSB repair. However, unregulated R-loop formation can cause DNA damage and genomic instability, which are potential drivers of cancer including leukemia. In this review, we discuss the current understanding of aberrant R-loop formation and how it influences genomic instability and leukemia development. We also consider the possibility of R-loops as therapeutic targets for cancer treatment.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24065966