Preclinical Detection of Early Glomerular Injury in Children with Kidney Diseases-Independently of Usual Markers of Kidney Impairment and Inflammation

Glomerular kidney diseases typically begin insidiously and can progress to end stage kidney failure. Early onset of therapy can slow down disease progression. Early diagnosis is required to ensure such timely therapy. The goal of our study was to evaluate protein biomarkers (BMs) for common nephropa...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-08, Vol.25 (17), p.9320
Main Authors: Rhode, Heidrun, Tautkus, Baerbel, Weigel, Friederike, Schitke, Julia, Metzing, Oliver, Boeckhaus, Jan, Kiess, Wieland, Gross, Oliver, Dost, Axel, John-Kroegel, Ulrike
Format: Article
Language:English
Subjects:
Adolescent
biomarker discovery
Biomarkers
Biomarkers - blood
Biomarkers - urine
Blood pressure
Child
Child, Preschool
Collagen
Creatinine
Early Diagnosis
Female
glomerulonephritis
Humans
Hypertension
Infant
Inflammation
Kidney diseases
Kidney Diseases - blood
Kidney Diseases - diagnosis
Kidney Diseases - etiology
Kidney Glomerulus - metabolism
Kidney Glomerulus - pathology
Male
Metabolic syndrome
Metabolites
Obesity
orphan disease
polycystic kidney disease
predictive analysis
Proteins
rare genetic disorders
Urine
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Summary:Glomerular kidney diseases typically begin insidiously and can progress to end stage kidney failure. Early onset of therapy can slow down disease progression. Early diagnosis is required to ensure such timely therapy. The goal of our study was to evaluate protein biomarkers (BMs) for common nephropathies that have been described for children with Alport syndrome. Nineteen candidate BMs were determined by commercial ELISA in children with congenital anomalies of the kidneys and urogenital tract, inflammatory kidney injury, or diabetes mellitus. It is particularly essential to search for kidney disease BMs in children because they are a crucial target group that likely exhibits early disease stages and in which misleading diseases unrelated to the kidney are rare. Only minor differences in blood between affected individuals and controls were found. However, in urine, several biomarker candidates alone or in combination seemed to be promising indicators of renal injury in early disease stages. The BMs of highest sensitivity and specificity were collagen type XIII, hyaluronan-binding protein 2, and complement C4-binding protein. These proteins are unrelated to inflammation markers or to risk factors for and signs of renal failure. In conclusion, our study evaluated several strong candidates for screening for early stages of kidney diseases and can help to establish early nephroprotective regimens.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25179320