Impact of height difference between coronary ostium and location of intracoronary pressure sensor on fractional flow reserve measurements

Background During fractional flow reserve (FFR) measurements, distal coronary pressure (Pd) can be influenced by hydrostatic pressure changes resulting from the height difference (HD) between the coronary ostium and the location of the distal pressure sensor. Aims We investigated the effect of aorto...

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Published in:PloS one 2023-01, Vol.18 (8)
Main Authors: Moon-Seung Soh, Hangyul Kim, Min Gyu Kang, Hyo Jin Lee, Seung Do Lee, Seok-Jae Hwang, Jin-Yong Hwang, Kyehwan Kim, Jeong-Rang Park, Hye-Ree Kim, Seung-Jea Tahk, Myeong-Ho Yoon, Hong-Seok Lim, Jin-Sin Koh
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Language:English
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Summary:Background During fractional flow reserve (FFR) measurements, distal coronary pressure (Pd) can be influenced by hydrostatic pressure changes resulting from the height difference (HD) between the coronary ostium and the location of the distal pressure sensor. Aims We investigated the effect of aortocoronary HD on the FFR measurements in each coronary artery. Methods In this retrospective cohort study, we analyzed 257 patients who underwent FFR measurements and coronary computed tomography (CCTA) within a year. Using CCTA, we measured HD as the vertical distance between the coronary ostium and a matched point of the distal coronary pressure sensor identified on coronary angiography. Results The location of the Pd sensor was higher than the coronary ostium in the left anterior descending artery (LAD) (-4.64 ± 1.15 cm) and lower than the coronary ostium in the left circumflex artery (LCX) (2.54 ± 1.05 cm) and right coronary artery (RCA) (2.03 ± 1.28 cm). The corrected FFR values by HD were higher in the LAD (0.78 ± 0.09 to 0.82 ± 0.09, P
ISSN:1932-6203