Vitamin D deficiency and post-stroke depression: A systematic review and meta-analysis

Objective: Low vitamin D levels have often been associated with depression as well as worsen stroke outcomes. With post-stroke depression (PSD) being an important factor contributing to poor recovery and rehabilitation and thereby poor functional outcomes, this study was undertaken to explore the ro...

Full description

Saved in:
Bibliographic Details
Published in:Brain disorders 2023-09, Vol.11, p.100096, Article 100096
Main Authors: Kurra, Nithin, Sudireddy, Kavya, Ramakrishnan, Manju, Boorle, Naga Vijaya Lakshmi Divya, Irfan, Shayan Ali, Jillella, Dinesh V, Gandrakota, Nikhila
Format: Article
Language:English
Subjects:
Depression
Neuropsychiatric
Post-stroke
Stroke
Vitamin D
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: Low vitamin D levels have often been associated with depression as well as worsen stroke outcomes. With post-stroke depression (PSD) being an important factor contributing to poor recovery and rehabilitation and thereby poor functional outcomes, this study was undertaken to explore the role of vitamin D deficiency in PSD and their correlation with stroke prognosis and outcomes. Methods: A systematic search of eligible studies from PubMed, MEDLINE, Cochrane CENTRAL, and Google Scholar were identified. Selected studies were those that met the inclusion criteria. Statistical analysis was conducted using Review Manager 5.4.1. A random-effects model was used to pool the data when heterogeneity was seen and so, results were reported in the standard mean differences within their corresponding 95 % confidence interval. Results: Our analysis showed statistically significant clinical depression in the Vitamin D deficient group on the BDI-II (SMD = 6.90 [3.32, 10.48]; p = 0.0002) and PHQ-9 (SMD = 3.20 [1.84, 4.56]; p 
ISSN:2666-4593
2666-4593
DOI:10.1016/j.dscb.2023.100096