The Determination of the Biocompatibility of New Compositional Materials, including Carbamide-Containing Heterocycles of Anti-Adhesion Agents for Abdominal Surgery

Due to traumatic injuries, including those from surgical procedures, adhesions occur in over 50% of cases, necessitating exclusive surgical intervention for treatment. However, preventive measures can be implemented during abdominal organ surgeries. These measures involve creating a barrier around i...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2024-02, Vol.29 (4), p.851
Main Authors: Kanasheva, Nurdana, Fedorishin, Dmitry A, Lyapunova, Maria V, Bukterov, Mikhail V, Kaidash, Olga A, Bakibaev, Abdigali A, Yerkassov, Rakhmetulla, Mashan, Togzhan, Nesmeyanova, Rimma, Ivanov, Vladimir V, Udut, Elena V, Tuguldurova, Vera P, Salina, Margarita V, Malkov, Victor S, Knyazev, Alexey S
Format: Article
Language:English
Subjects:
Abdomen
Adhesion
Adsorption
Analysis
anti-adhesion agents
Anti-inflammatory agents
Antioxidants
barrier films
Biocompatibility
Biodegradable materials
Biological products
Blood proteins
carbamide-containing heterocycles
Carboxymethylcellulose Sodium
Cellulose
Clinical trials
Composite materials
Cytotoxicity
Experiments
Gynecological surgery
Humans
Hyaluronic Acid
Intestinal obstruction
Macrophages
Proteins
Surgery
Tissue Adhesions - prevention & control
Urea
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Summary:Due to traumatic injuries, including those from surgical procedures, adhesions occur in over 50% of cases, necessitating exclusive surgical intervention for treatment. However, preventive measures can be implemented during abdominal organ surgeries. These measures involve creating a barrier around internal organs to forestall adhesion formation in the postoperative phase. Yet, the effectiveness of the artificial barrier relies on considerations of its biocompatibility and the avoidance of adverse effects on the body. This study explores the biocompatibility aspects, encompassing hemocompatibility, cytotoxicity, and antibacterial and antioxidant activities, as well as the adhesion of blood serum proteins and macrophages to the surface of new composite film materials. The materials, derived from the sodium salt of carboxymethylcellulose modified by glycoluril and allantoin, were investigated. The research reveals that film materials with a heterocyclic fragment exhibit biocompatibility comparable to commercially used samples in surgery. Notably, film samples developed with glycoluril outperform the effects of commercial samples in certain aspects.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29040851