Formulation and Characterization of Mupirocin Nanomicelles in Insulin-Based Gel for Dermatological Application

ABSTRACT Aim: To produce and analyze mupirocin nanomicelle (MP-NM) in insulin-based gel. Procedures: MP-NM was prepared using solvent evaporation with Tween 80 as a surfactant. HPMC polymer prepared gel. MP-NM was characterized by globular diameter, polydispersity index (PDI), pH, entrapment efficie...

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Published in:Journal of pharmacy & bioallied science 2023-07, Vol.15 (Suppl 2), p.S1178-S1181
Main Authors: Zubairi, Maysaa B., Abd, Abdulkareem H., Al-lami, Mohammed S.
Format: Article
Language:English
Subjects:
Chemical properties
Drug delivery
Evaporation
Insulin
Methicillin
Mupirocin
nano-drug delivery
nanomicelle
Original
Original Article
Surface active agents
Transmission electron microscopy
tween 80
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Summary:ABSTRACT Aim: To produce and analyze mupirocin nanomicelle (MP-NM) in insulin-based gel. Procedures: MP-NM was prepared using solvent evaporation with Tween 80 as a surfactant. HPMC polymer prepared gel. MP-NM was characterized by globular diameter, polydispersity index (PDI), pH, entrapment efficiency (EE), and transmission electron microscopy (TEM). NM MP release was studied in vitro. Results: The revolutionary MP-NM in insulin-based gel dissolves MP completely without precipitation due to its unique physical and chemical properties. MP had 8.64 ± 0.2 nm globular diameter, high EE (98.85 ± 0.01%), and normal homogeneous dispersion (PDI, 0.143 ± 0.003) in NM. MP's formula showed rapid first-order kinetics release. Conclusion: To our knowledge, this is the first MP-NM nano-drug delivery system employing insulin-based gel. It has promising pre-clinical and clinical uses.
ISSN:0976-4879
0975-7406
0975-7406
DOI:10.4103/jpbs.jpbs_172_23