A case of severe paraquat poisoning treated by continuous hemodiafiltration without sequelae

Background In a suicide attempt, a 49‐year‐old male ingested pesticides. He arrived at the hospital restless and vomiting blue liquid. Case Presentation The patient was diagnosed with paraquat poisoning at a lethal dose and experienced renal dysfunction during treatment. He underwent continuous hemo...

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Published in:Acute medicine & surgery 2023-01, Vol.10 (1), p.e833-n/a
Main Authors: Hisamura, Masaki, Ogura, Tomoyuki, Tokuda, Mitsuhiro, Nakamura, Motohiro, Kenichiro, Sonoda, Ando, Yoji, Nakata, Kazuyuki, Taguchi, Hirokazu
Format: Article
Language:English
Subjects:
Blood
Case Report
Collagen
Consciousness
Continuous hemodiafiltration
Creatinine
Fatalities
Hospitalization
Lungs
paraquat
Parenteral nutrition
Patients
pesticides
Poisoning
Potassium
Pulmonary fibrosis
suicide
Ulcers
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creator Hisamura, Masaki
Ogura, Tomoyuki
Tokuda, Mitsuhiro
Nakamura, Motohiro
Kenichiro, Sonoda
Ando, Yoji
Nakata, Kazuyuki
Taguchi, Hirokazu
description Background In a suicide attempt, a 49‐year‐old male ingested pesticides. He arrived at the hospital restless and vomiting blue liquid. Case Presentation The patient was diagnosed with paraquat poisoning at a lethal dose and experienced renal dysfunction during treatment. He underwent continuous hemodiafiltration (CHDF). Hemodialysis was temporarily initiated and found to improve renal function. He was discharged on day 36 in good condition. He remains well with only mild renal impairment and no pulmonary fibrosis, 240 days after the incident. The fatality rate of paraquat poisoning is approximately 80%, regardless of the treatment. Early hemodialysis combined with CHDF within 4 h has been reported to be effective. In this case, CHDF was initiated approximately 3 h after paraquat administration and showed a successful outcome. Conclusion CHDF should be performed as soon as possible to treat paraquat poisoning. This study explored a case study of a patient with acute paraquat poisoning. We were able to successfully treat this patient using a combination of early continuous hemodiafiltration and later hemodialysis, and after 240 days, he has experienced no common negative sequalae.
doi_str_mv 10.1002/ams2.833
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He arrived at the hospital restless and vomiting blue liquid. Case Presentation The patient was diagnosed with paraquat poisoning at a lethal dose and experienced renal dysfunction during treatment. He underwent continuous hemodiafiltration (CHDF). Hemodialysis was temporarily initiated and found to improve renal function. He was discharged on day 36 in good condition. He remains well with only mild renal impairment and no pulmonary fibrosis, 240 days after the incident. The fatality rate of paraquat poisoning is approximately 80%, regardless of the treatment. Early hemodialysis combined with CHDF within 4 h has been reported to be effective. In this case, CHDF was initiated approximately 3 h after paraquat administration and showed a successful outcome. Conclusion CHDF should be performed as soon as possible to treat paraquat poisoning. This study explored a case study of a patient with acute paraquat poisoning. We were able to successfully treat this patient using a combination of early continuous hemodiafiltration and later hemodialysis, and after 240 days, he has experienced no common negative sequalae.</description><identifier>ISSN: 2052-8817</identifier><identifier>EISSN: 2052-8817</identifier><identifier>DOI: 10.1002/ams2.833</identifier><identifier>PMID: 36895322</identifier><language>eng</language><publisher>United States: John Wiley &amp; Sons, Inc</publisher><subject>Blood ; Case Report ; Collagen ; Consciousness ; Continuous hemodiafiltration ; Creatinine ; Fatalities ; Hospitalization ; Lungs ; paraquat ; Parenteral nutrition ; Patients ; pesticides ; Poisoning ; Potassium ; Pulmonary fibrosis ; suicide ; Ulcers</subject><ispartof>Acute medicine &amp; surgery, 2023-01, Vol.10 (1), p.e833-n/a</ispartof><rights>2023 The Authors. published by John Wiley &amp; Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine.</rights><rights>2023 The Authors. 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surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hisamura, Masaki</au><au>Ogura, Tomoyuki</au><au>Tokuda, Mitsuhiro</au><au>Nakamura, Motohiro</au><au>Kenichiro, Sonoda</au><au>Ando, Yoji</au><au>Nakata, Kazuyuki</au><au>Taguchi, Hirokazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of severe paraquat poisoning treated by continuous hemodiafiltration without sequelae</atitle><jtitle>Acute medicine &amp; surgery</jtitle><addtitle>Acute Med Surg</addtitle><date>2023-01</date><risdate>2023</risdate><volume>10</volume><issue>1</issue><spage>e833</spage><epage>n/a</epage><pages>e833-n/a</pages><issn>2052-8817</issn><eissn>2052-8817</eissn><abstract>Background In a suicide attempt, a 49‐year‐old male ingested pesticides. 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source Wiley Online Library Open Access; Publicly Available Content Database; PubMed Central
subjects Blood
Case Report
Collagen
Consciousness
Continuous hemodiafiltration
Creatinine
Fatalities
Hospitalization
Lungs
paraquat
Parenteral nutrition
Patients
pesticides
Poisoning
Potassium
Pulmonary fibrosis
suicide
Ulcers
title A case of severe paraquat poisoning treated by continuous hemodiafiltration without sequelae
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