Functional Defect of Neutrophils Causing Dermatophytosis: Case Report

: NADPH-oxidase and myeloperoxidase (MPO) play an important role on defense against pathogenic microorganisms. Defects on these mechanisms have been described in association with recurrent infections due to such as and We describe a patient with partial disturbance of intracellular microorganism des...

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Bibliographic Details
Published in:Journal of fungi (Basel) 2020-10, Vol.6 (4), p.238
Main Authors: Constantino-Silva, Rosemeire N, Perazzio, Sandro F, Weidebach, Nicolas de Albuquerque, Grumach, Anete S
Format: Article
Language:English
Subjects:
Case Report
chronic granulomatous disease
fungal infection
myeloperoxidase
NCF1
neutrophil
Trichophyton
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Summary:: NADPH-oxidase and myeloperoxidase (MPO) play an important role on defense against pathogenic microorganisms. Defects on these mechanisms have been described in association with recurrent infections due to such as and We describe a patient with partial disturbance of intracellular microorganism destruction clinically manifested by recurrent fungal infection. A 58-year-old male rural farmer has suffered with superficial mycosis affecting hands, nails and right ankle persisting for 20 years. He was treated with several antifungal drugs with no improvement. Mycological scraping isolated . Immunological evaluation showed impaired T cell proliferation to and impaired neutrophil burst oxidative after specific stimulation with . The patient's DNA was extracted from peripheral blood leukocytes for whole exome sequencing (WES) analysis. Two heterozygous variants of undetermined significance were screened accordingly: (1) A332V (c.995G>A; rs28730837); and (2) G83R (c.247G>A; rs139225348). Functional leukocyte evaluation with heterozygous variants in MPO and NCF1 suggest that these defects were associated with the susceptibility to dermatophytosis in our patient. We have developed a fast, effective and safe trial for screening individuals with yeast infections.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof6040238