Decline in measured glomerular filtration rate is associated with simple renal cyst in Chinese patients with type 2 diabetes

• Published in: Journal of diabetes investigation 2024-01, Vol.15 (1), p.26-33
• Main Authors: Qiaoling, Fu, Jingyi, Lu, Yan, Li, Wen, Li, Chaoying, Yang, Mingliang, Zhang, Lei, Zhang
• Format: Article
• Language: English
• Subjects: Acetic acid; Alcohol; Blood pressure; Body mass index; Cholesterol; Creatinine; Cysts; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes mellitus, type 2; Glomerular filtration rate; Hemoglobin; Hypertension; Hyperuricemia; Isotopes; Kidney diseases; Kidneys; Lipoproteins; Normal distribution; Original; Peptides; Renal cyst; Risk factors; Scintigraphy; Special Issue: Diabetes and Big Data; Statistical analysis; Student's t-test; Technetium; Ultrasonic imaging; Uric acid; Urogenital system; Variables; Variance analysis
• ISSN: 2040-1116; 2040-1124
• DOI: 10.1111/jdi.14120

Aims/Introduction Simple renal cysts (SRC) are associated with age, hypertension and hyperuricemia, which are risk factors of renal impairment. This study aimed to investigate the prevalence of SRC and its association with measured glomerular filtration rate (mGFR) in patients with type 2 diabetes mellitus in China. Methods A total of 3,552 patients with type 2 diabetes mellitus admitted to Shanghai Sixth People's Hospital from January 2012 to December 2016 were investigated. All participants were diagnosed as SRC by color Doppler, and all participants were measured for GFR by using dynamic renal scintigraphy with technetium‐99m‐diethylene triamine peta‐acetic acid. Results The prevalence of SRC was 17.4% (619 cases). Participants with SRC had significantly lower mGFR values than those without SRC (86.16 ± 26.20 vs 94.88 ± 23.98 mL/min/1.73 m2, P