Role of Melatonin in the Onset of Metabolic Syndrome in Women

Metabolic syndrome (MetS) is a constellation of several associated cardiometabolic risk factors that increase the risk of developing type 2 diabetes mellitus (T2DM), cardiovascular diseases, and mortality. The role of hormonal factors in the development of MetS is assumed. In women, an insulin-resis...

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Bibliographic Details
Published in:Biomedicines 2023-05, Vol.11 (6), p.1580
Main Authors: Peneva, Vania Miloucheva, Terzieva, Dora Dimitrova, Mitkov, Mitko Dimitrov
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose tissues
Body weight
Cardiovascular diseases
Development and progression
Dextrose
Diabetes mellitus (non-insulin dependent)
Gender differences
Ghrelin
Glucose
Glucose metabolism
Hypertension
Hypothalamus
Insulin
Insulin resistance
Leptin
Medical research
Medicine, Experimental
Melatonin
Metabolic disorders
Metabolic syndrome
Mortality
Obesity
Physiological aspects
Polycystic ovary syndrome
Review
Risk factors
Suprachiasmatic nucleus
Type 2 diabetes
Women
Womens health
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Summary:Metabolic syndrome (MetS) is a constellation of several associated cardiometabolic risk factors that increase the risk of developing type 2 diabetes mellitus (T2DM), cardiovascular diseases, and mortality. The role of hormonal factors in the development of MetS is assumed. In women, an insulin-resistant state that is associated with polycystic ovarian syndrome and increased deposition of intra-abdominal adipose tissue promotes the development of MetS and increases cardiovascular risk. The neuroendocrine hormone melatonin is secreted mainly at night under the regulatory action of the suprachiasmatic nucleus in the hypothalamus. Melatonin secretion is influenced by exogenous factors such as light and seasons and endogenous factors such as age, sex, and body weight. At present, the role of melatonin in metabolic disorders in humans is not fully understood. In this review, we set out to analyze the relationship of melatonin with the main features of MetS in women. Data from experimental and clinical studies on the role of melatonin in glucose metabolism and on the involvement of melatonin in lipid disturbances in MetS are reviewed. The complex influence of melatonin on hypertension is discussed. The changes in melatonin, leptin, and ghrelin and their relation to various metabolic processes and vascular dysfunction are discussed.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11061580