Neural population dynamics in motor cortex are different for reach and grasp

• Published in: eLife 2020-11, Vol.9
• Main Authors: Suresh, Aneesha K, Goodman, James M, Okorokova, Elizaveta V, Kaufman, Matthew, Hatsopoulos, Nicholas G, Bensmaia, Sliman J
• Format: Article
• Language: English
• Subjects: Animal behavior; Animals; Brain Mapping; hand; Hand Strength - physiology; Macaca mulatta; motor control; Motor Cortex - cytology; Motor Cortex - physiology; movement; Movement - physiology; Neurons; Neurons - physiology; Neurophysiology; Neuroscience; Population biology; Psychomotor Performance - physiology; rhesus macaque; Short Report
• ISSN: 2050-084X; 2050-084X
• DOI: 10.7554/eLife.58848

Low-dimensional linear dynamics are observed in neuronal population activity in primary motor cortex (M1) when monkeys make reaching movements. This population-level behavior is consistent with a role for M1 as an autonomous pattern generator that drives muscles to give rise to movement. In the present study, we examine whether similar dynamics are also observed during grasping movements, which involve fundamentally different patterns of kinematics and muscle activations. Using a variety of analytical approaches, we show that M1 does not exhibit such dynamics during grasping movements. Rather, the grasp-related neuronal dynamics in M1 are similar to their counterparts in somatosensory cortex, whose activity is driven primarily by afferent inputs rather than by intrinsic dynamics. The basic structure of the neuronal activity underlying hand control is thus fundamentally different from that underlying arm control.