HO-1 is a favorable prognostic factor for HBV-HCC patients who underwent hepatectomy

More than 500,000 people suffered from hepatocelluar carcinoma (HCC) annually and the relative incidence to mortality rate indicates its unfavorable prognosis. Several studies have proved that heme-oxygenase-1 (HO-1) is indirectly engaged in the invasion and the metastasis of some types of malignanc...

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Bibliographic Details
Published in:Cancer management and research 2018-01, Vol.10, p.6049-6059
Main Authors: Yeh, Chun-Nan, Wu, Ren-Chin, Cheng, Chi-Tung, Tsai, Chun-Yi, Chang, Yau-Ren, Yeh, Ta-Sen, Wu, Tsung-Han, Lee, Wei-Chen, Chiang, Kun-Chun
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Cancer
Cancer metastasis
Carcinoma
Care and treatment
Cell adhesion & migration
Cell cycle
Cell growth
Cyclin-dependent kinases
EDTA
Genes
HBV
HCC
Heme
Hepatectomy
Hepatitis
Hepatitis B
Hepatitis B virus
Hepatocellular carcinoma
HO-1
Human migration
Immunoglobulins
Immunohistochemistry
Infection
Kinases
Laboratories
Lung cancer
Medical prognosis
Metastasis
Original Research
Patient outcomes
Prostate
Prostate cancer
Protein expression
Proteins
Risk factors
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Summary:More than 500,000 people suffered from hepatocelluar carcinoma (HCC) annually and the relative incidence to mortality rate indicates its unfavorable prognosis. Several studies have proved that heme-oxygenase-1 (HO-1) is indirectly engaged in the invasion and the metastasis of some types of malignancies, including breast cancer, prostate cancer, and lung cancer. The role of HO-1 in hepatitis B virus (HBV)-related HCC is still not clarified. The Western blot, doubling time, cell cycle analysis, migration assay, invasion assay, gene transfection, xenograft animal model, immunohistochemistry staining, and clinical validation study were applied in this study. HO-1 overexpression not only decreased the growth but also inhibited the migration and invasion in human HBV-HCC cells (Hep-3B vs PLC/PRF/5). The inhibitory effect on growth, migration, and invasion is further demonstrated by the overexpression of HO-1 in Hep-3B cell by transfection study. Furthermore, HO-1 decreasing the growth of HBV-HCC was confirmed in animal study. The clinical validation illustrated that higher HO1 expression was also associated with favorable disease-free survival of HBV-HCC patients who underwent hepatectomy. We identified HO-1 as a favorable prognostic factor for HBV-HCC patients who underwent hepatectomy.
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S186931