Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cells in vitro

Neural stem cells (NSCs) provide promising approaches for investigating embryonic neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and for designing drug-screening systems. Such cells also have an application in regenerative medicine. The most convenient and acce...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2020-10, Vol.8, p.815-815
Main Authors: Galiakberova, Adelya A., Dashinimaev, Erdem B.
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
ESC
iPSC
neural stem cells
neurogenesis
NSC
pluripotent stem cells
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Summary:Neural stem cells (NSCs) provide promising approaches for investigating embryonic neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and for designing drug-screening systems. Such cells also have an application in regenerative medicine. The most convenient and acceptable source of NSCs is pluripotent stem cells (embryonic stem cells or induced pluripotent stem cells). However, there are many different protocols for the induction and differentiation of NSCs, and these result in a wide range of neural cell types. This review is intended to summarize the knowledge accumulated, to date, by workers in this field. It should be particularly useful for researchers who are beginning investigations in this area of cell biology.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2020.00815