Reshaping Our Knowledge: Advancements in Understanding the Immune Response to Human Respiratory Syncytial Virus

Human respiratory syncytial virus (hRSV) is a significant cause of respiratory tract infections, particularly in young children and older adults. In this review, we aimed to comprehensively summarize what is known about the immune response to hRSV infection. We described the innate and adaptive immu...

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Bibliographic Details
Published in:Pathogens (Basel) 2023-09, Vol.12 (9), p.1118
Main Authors: Attaianese, Federica, Guiducci, Sara, Trapani, Sandra, Barbati, Federica, Lodi, Lorenzo, Indolfi, Giuseppe, Azzari, Chiara, Ricci, Silvia
Format: Article
Language:English
Subjects:
Amino acids
Antibodies
Antigen presentation
Antigens
Cardiovascular disease
Care and treatment
Cell cycle
Congenital diseases
Development and progression
Development strategies
Disease prevention
Genomes
Glycoproteins
Growth factors
Health aspects
Heparan sulfate
Immune response
Immune system
Immunological memory
Infections
Inflammation
Inflammatory response
Kinases
Lymphocytes
Lymphocytes T
Natural killer cells
Older people
Pneumonia
Polypeptides
prevention strategy
Proteins
Respiratory syncytial virus
Respiratory syncytial virus infection
Respiratory tract
Respiratory tract infection
Review
RNA polymerase
RSV
syncytial respiratory virus
Viruses
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Summary:Human respiratory syncytial virus (hRSV) is a significant cause of respiratory tract infections, particularly in young children and older adults. In this review, we aimed to comprehensively summarize what is known about the immune response to hRSV infection. We described the innate and adaptive immune components involved, including the recognition of RSV, the inflammatory response, the role of natural killer (NK) cells, antigen presentation, T cell response, and antibody production. Understanding the complex immune response to hRSV infection is crucial for developing effective interventions against this significant respiratory pathogen. Further investigations into the immune memory generated by hRSV infection and the development of strategies to enhance immune responses may hold promise for the prevention and management of hRSV-associated diseases.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens12091118