Natural reduced water suppressed anxiety and protected the heightened oxidative stress in rats

In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water , have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis. Natural re...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2017-01, Vol.13, p.2357-2362
Main Authors: Masuda, Koji, Tanaka, Yoshihiro, Kanehisa, Masayuki, Ninomiya, Taiga, Inoue, Ayako, Higuma, Haruka, Kawashima, Chiwa, Nakanishi, Mari, Okamoto, Kana, Akiyoshi, Jotaro
Format: Article
Language:English
Subjects:
8-Hydroxydeoxyguanosine
8-OH-dG
Antidepressants
Anxiety
Aquaporins
Behavior
Camcorders
Cardiovascular disease
Deoxyribonucleic acid
Depression
Depression (Mood disorder)
Diabetes
DNA
Experiments
Health aspects
Medical research
Mental depression
Original Research
Oxidative stress
Rat
Stress
University faculty
Water
Yoga
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Summary:In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water , have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis. Natural reduced water and distilled water were administered to rats for 180 consecutive days, and their effect on anxiety-like behavior and depression was examined by using elevated plus maze, light/dark, forced swimming, and conditioned fear tests. Before and after administration of natural reduced or distilled water, we performed blood and urine analyses. Natural reduced water exhibited anxiolytic-like effects in the conditioned fear and elevated plus maze tests. The mean levels of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the natural reduced water were significantly lower than the distilled water group. Natural reduced water group also showed decrease in blood-urea nitrogen levels compared with the distilled water group. These results indicate that natural reduced water may decrease anxiety-related behaviors and prevent heightened oxidative stress.
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/ndt.s138289