Adhesion Deregulation in Acute Myeloid Leukaemia

Cell adhesion is a process through which cells interact with and attach to neighboring cells or matrix using specialized surface cell adhesion molecules (AMs). Adhesion plays an important role in normal haematopoiesis and in acute myeloid leukaemia (AML). AML blasts express many of the AMs identifie...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2019-01, Vol.8 (1), p.66
Main Authors: Gruszka, Alicja M, Valli, Debora, Restelli, Cecilia, Alcalay, Myriam
Format: Article
Language:English
Subjects:
acute myeloid leukaemia
Acute myeloid leukemia
adhesion molecules
Animals
Antigens
Bone marrow
Cell Adhesion
Cell adhesion & migration
Cell adhesion molecules
Cell Adhesion Molecules - metabolism
Cell Movement
Chemokines
Chemotherapy
Cytoskeleton
EMT
Epithelial-Mesenchymal Transition
Glycoproteins
Homing behavior
Humans
Leukemia
Leukemia, Myeloid, Acute - pathology
Ligands
Medical prognosis
Mesenchyme
Metastases
Neoplastic Stem Cells - pathology
Peripheral blood
Proteins
Review
Signal transduction
Spleen
Stem cells
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Summary:Cell adhesion is a process through which cells interact with and attach to neighboring cells or matrix using specialized surface cell adhesion molecules (AMs). Adhesion plays an important role in normal haematopoiesis and in acute myeloid leukaemia (AML). AML blasts express many of the AMs identified on normal haematopoietic precursors. Differential expression of AMs between normal haematopoietic cells and leukaemic blasts has been documented to a variable extent, likely reflecting the heterogeneity of the disease. AMs govern a variety of processes within the bone marrow (BM), such as migration, homing, and quiescence. AML blasts home to the BM, as the AM-mediated interaction with the niche protects them from chemotherapeutic agents. On the contrary, they detach from the niches and move from the BM into the peripheral blood to colonize other sites, i.e., the spleen and liver, possibly in a process that is reminiscent of epithelial-to-mesenchymal-transition in metastatic solid cancers. The expression of AMs has a prognostic impact and there are ongoing efforts to therapeutically target adhesion in the fight against leukaemia.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells8010066