First Case of Staphylococci Carrying Linezolid Resistance Genes from Laryngological Infections in Poland

Linezolid is currently used to treat infections caused by multidrug-resistant Gram-positive cocci. Both linezolid-resistant (LRSA) and coagulase-negative staphylococci (CoNS) strains have been collected worldwide. Two isolates carrying linezolid resistance genes were recovered from laryngological pa...

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Published in:Pathogens (Basel) 2021-03, Vol.10 (3), p.335
Main Authors: Michalik, Michał, Kosecka-Strojek, Maja, Wolska, Mariola, Samet, Alfred, Podbielska-Kubera, Adrianna, Międzobrodzki, Jacek
Format: Article
Language:English
Subjects:
antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
chronic sinusitis
Coagulase
Endoscopy
Etiology
Gene expression
Genes
Gram-positive cocci
laryngological infections
Linezolid
Methicillin
Multidrug resistance
Mutation
Patients
Penicillin
Proteins
Ribosomal proteins
Sinuses
Sinusitis
Staphylococcus aureus
Staphylococcus haemolyticus
Staphylococcus infections
Surgery
Typing
Virulence
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Summary:Linezolid is currently used to treat infections caused by multidrug-resistant Gram-positive cocci. Both linezolid-resistant (LRSA) and coagulase-negative staphylococci (CoNS) strains have been collected worldwide. Two isolates carrying linezolid resistance genes were recovered from laryngological patients and characterized by determining their antimicrobial resistance patterns and using molecular methods such as typing, MLST, SCC typing, detection of virulence genes and operon expression, and analysis of antimicrobial resistance determinants. Both isolates were multidrug resistant, including resistance to methicillin. The strain was identified as ST-398/t4474/SCC IVe, harboring adhesin, hemolysin genes, and the operon. The strain was identified as ST-42/ -positive and harbored hemolysin genes. Linezolid resistance in strain was associated with the mutations in the ribosomal proteins L3 and L4, and in , resistance was associated with the presence of gene. Moreover, strain harbored and genes. We identified the first case of staphylococci carrying linezolid resistance genes from patients with chronic sinusitis in Poland. Since both and CoNS are the most common etiological factors in laryngological infections, monitoring of such infections combined with surveillance and infection prevention programs is important to decrease the number of linezolid-resistant staphylococcal strains.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens10030335