Acoustic Bubble and Magnetic Actuation-Based Microrobot for Enhanced Multiphase Drug Delivery Efficiency

• Published in: Micromachines (Basel) 2023-11, Vol.14 (12), p.2169
• Main Authors: Park, Jihyeok, Kim, Youngkwang, Jeong, Jinwon, Jang, Deasung, Kim, Daegeun, Chung, Sangkug
• Format: Article
• Language: English
• Subjects: acoustic bubble; Acoustics; Actuation; Blood vessels; Bubbles; Cancer therapies; cavitational microstreaming; Chemotherapy; Drug delivery systems; Drug therapy; Drugs; Efficiency; Encapsulation; Flow distribution; Flow velocity; High speed cameras; Hydrogels; Investigations; Laparoscopy; Liquid metals; Magnetic fields; Magnetic fluids; magnetic liquid metal; Methods; microrobot; Microrobots; Multiphase; Reynolds number; Side effects; target drug delivery technology; Three dimensional printing; Vehicles
• ISSN: 2072-666X; 2072-666X
• DOI: 10.3390/mi14122169

This paper proposes an acoustic bubble and magnetic actuation-based microrobot for enhancing multiphase drug delivery efficiency. The proposed device can encapsulate multiphase drugs, including liquids, using the two bubbles embedded within the microtube. Additionally, using the magnetic actuation of the loaded magnetic liquid metal, it can deliver drugs to target cells. This study visualized the flow patterns generated by the oscillating bubble within the tube to validate the drug release principle. In addition, to investigate the effect of the oscillation properties of the inner bubble on drug release, the oscillation amplitude of the inner bubble was measured under various experimental variables using a high-speed camera. Subsequently, we designed a microrobot capable of encapsulating bubbles, drugs, and magnetic liquid metal and fabricated it using microfabrication technology based on ultra-precision 3D printing. As a proof of concept, we demonstrated the transport and drug release of the microrobot encapsulating the drug in a Y-shaped channel simulating a blood vessel. The proposed device is anticipated to enhance the efficiency of drug therapy by minimizing drug side effects, reducing drug administration frequency, and improving the stability of the drug within the body. This paper is expected to be applicable not only to targeted drug delivery but also to various biomedical fields, such as minimally invasive surgery and cell manipulation, by effectively delivering multiphase drugs using the simple structure of a microrobot.