Is choline kinase alpha a drug target for obesity?

Choline kinase alpha (ChoKα) is a therapeutic target being developed for a variety of diseases, from cancer to rheumatoid arthritis and from parasites to bacterial infections. Nevertheless, the therapeutic potential of this drug target seems not exhausted and may end up as a possible solution for a...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2024-11, Vol.15, p.1492753
Main Authors: Lacal, Juan Carlos, Ibrahim, Salam A, Zimmerman, Tahl
Format: Article
Language:English
Subjects:
adipogenesis
Animals
choline
choline kinase
Choline Kinase - antagonists & inhibitors
Choline Kinase - metabolism
Endocrinology
Humans
obesity
Obesity - drug therapy
thermogenesis
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Summary:Choline kinase alpha (ChoKα) is a therapeutic target being developed for a variety of diseases, from cancer to rheumatoid arthritis and from parasites to bacterial infections. Nevertheless, the therapeutic potential of this drug target seems not exhausted and may end up as a possible solution for a larger variety of conditions. Here we present our working model for how ChoKα could play a role in obesity and for how drugs being developed as therapeutics for other diseases using ChoKα as a target, could be repurposed as prophylactic treatments for obesity. We also present preliminary observations in support of our model.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2024.1492753